Hepatitis C virus core mutations reduce the sensitivity of a fluorescence enzyme immunoassay.

نویسندگان

  • H Tokita
  • G R Kaufmann
  • M Matsubayashi
  • I Okuda
  • T Tanaka
  • H Harada
  • M Mukaide
  • K Suzuki
  • D A Cooper
چکیده

Four of 107 samples obtained from hepatitis C virus (HCV) carriers showed lower HCV core antigen levels in a fluorescence enzyme immunoassay (FEIA) than expected from corresponding HCV RNA levels. Nucleotide sequencing revealed a mutation in the HCV core region (Thr49Pro) that appears to have reduced the FEIA sensitivity.

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عنوان ژورنال:
  • Journal of clinical microbiology

دوره 38 9  شماره 

صفحات  -

تاریخ انتشار 2000